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Gene essentiality and synthetic lethality in haploid human cells

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Science  27 Nov 2015:
Vol. 350, Issue 6264, pp. 1092-1096
DOI: 10.1126/science.aac7557

Article Information

vol. 350 no. 6264 1092-1096

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History: 
  • Received for publication September 28, 2014
  • Accepted for publication October 1, 2015

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Author Information

  1. Vincent A. Blomen1,*,
  2. Peter Májek2,*,
  3. Lucas T. Jae1,*,
  4. Johannes W. Bigenzahn2,
  5. Joppe Nieuwenhuis1,
  6. Jacqueline Staring1,
  7. Roberto Sacco2,
  8. Ferdy R. van Diemen1,
  9. Nadine Olk2,
  10. Alexey Stukalov2,
  11. Caleb Marceau3,
  12. Hans Janssen1,
  13. Jan E. Carette3,
  14. Keiryn L. Bennett2,
  15. Jacques Colinge2,4,,
  16. Giulio Superti-Furga2,5,,
  17. Thijn R. Brummelkamp1,2,6,
  1. 1Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.
  2. 2CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
  3. 3Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA.
  4. 4University of Montpellier, Institut de Recherche en Cancérologie de Montpellier Inserm U1194, Institut régional du Cancer Montpellier, 34000 Montpellier, France.
  5. 5Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
  6. 6Cancer Genomics Center (CGC.nl), Plesmanlaan 121, 1066CX, Amsterdam, Netherlands.
  1. Corresponding author. E-mail: jacques.colinge{at}inserm.fr (J.C.); gsuperti{at}cemm.at (G. S.-F.); t.brummelkamp{at}nki.nl (T.R.B.)
  1. * These authors contributed equally to this work.

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