Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

Luhan Yang; Marc Güell; Dong Niu; Haydy George; Emal Lesha; Dennis Grishin; John Aach; Ellen Shrock; Weihong Xu; Jürgen Poci; Rebeca Cortazio; Robert A. Wilkinson; Jay A. Fishman; George Church

doi:10.1126/science.aad1191

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Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

Luhan Yang¹,²,³,*,†,
Marc Güell¹,²,³,†,
Dong Niu¹,⁴,†,
Haydy George¹,†,
Emal Lesha¹,
Dennis Grishin¹,
John Aach¹,
Ellen Shrock¹,
Weihong Xu⁶,
Jürgen Poci¹,
Rebeca Cortazio¹,
Robert A. Wilkinson⁵,
Jay A. Fishman⁵,
George Church¹,²,³,*

¹Department of Genetics, Harvard Medical School, Boston, MA, USA.
²Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.
³eGenesis Biosciences, Boston, MA 02115, USA.
⁴College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
⁵Transplant Infectious Disease and Compromised Host Program, Massachusetts General Hospital, Boston, MA 02115, USA.
⁶Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

↵*Corresponding author. E-mail: gchurch{at}genetics.med.harvard.edu (G.C.); luhan.yang{at}egenesisbio.com (L.Y.)

↵† These authors contributed equally to this work.

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Science 27 Nov 2015:
Vol. 350, Issue 6264, pp. 1101-1104
DOI: 10.1126/science.aad1191

Luhan Yang

1Department of Genetics, Harvard Medical School, Boston, MA, USA.

2Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.

3eGenesis Biosciences, Boston, MA 02115, USA.

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For correspondence: gchurch@genetics.med.harvard.edu luhan.yang@egenesisbio.com

Marc Güell

1Department of Genetics, Harvard Medical School, Boston, MA, USA.

2Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.

3eGenesis Biosciences, Boston, MA 02115, USA.

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Dong Niu

1Department of Genetics, Harvard Medical School, Boston, MA, USA.

4College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.

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Haydy George

1Department of Genetics, Harvard Medical School, Boston, MA, USA.

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Emal Lesha

1Department of Genetics, Harvard Medical School, Boston, MA, USA.

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Dennis Grishin

1Department of Genetics, Harvard Medical School, Boston, MA, USA.

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John Aach

1Department of Genetics, Harvard Medical School, Boston, MA, USA.

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Ellen Shrock

1Department of Genetics, Harvard Medical School, Boston, MA, USA.

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Weihong Xu

6Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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Jürgen Poci

1Department of Genetics, Harvard Medical School, Boston, MA, USA.

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Rebeca Cortazio

1Department of Genetics, Harvard Medical School, Boston, MA, USA.

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Robert A. Wilkinson

5Transplant Infectious Disease and Compromised Host Program, Massachusetts General Hospital, Boston, MA 02115, USA.

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Jay A. Fishman

5Transplant Infectious Disease and Compromised Host Program, Massachusetts General Hospital, Boston, MA 02115, USA.

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George Church

1Department of Genetics, Harvard Medical School, Boston, MA, USA.

2Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.

3eGenesis Biosciences, Boston, MA 02115, USA.

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For correspondence: gchurch@genetics.med.harvard.edu luhan.yang@egenesisbio.com

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