Erratum for the Report “14-Step Synthesis of (+)-Ingenol from (+)-3-Carene” by L. Jørgensen, S. J. McKerrall, C. A. Kuttruff, F. Ungeheuer, J. Felding, P. S. Baran

See allHide authors and affiliations

Science  27 Nov 2015:
Vol. 350, Issue 6264, aad8935
DOI: 10.1126/science.aad8935

In the Report “14-Step Synthesis of (+)-Ingenol from (+)-3-Carene,” ingenol was assigned a positive optical rotation. However, continued studies in the isolation and synthesis of ingenol have led the authors to revisit this measurement. An earlier isolation report indicated a positive optical rotation for natural ingenol (1), and the authors likewise originally measured a positive optical rotation of their synthetic product. However, multiple follow-up measurements that the authors and their collaborators recently carried out on larger quantities of both natural and synthetic samples of ingenol indicate a negative optical rotation. None of the conclusions in the Report is affected.


Navigate This Article