Mitochondria shape cardiac metabolism

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Science  04 Dec 2015:
Vol. 350, Issue 6265, pp. 1162-1163
DOI: 10.1126/science.aad8222

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The adult human heart is an intensely metabolically active organ, with a content of mitochondria that primarily use fatty acids for adenosine triphosphate (ATP) production. Two papers in this issue, by Gong et al. (1) on page 1220 and by Wai et al. (2) on page 1221, illustrate the importance of mitochondrial quality control in cardiac function during fetal life and in the adult heart.