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Teamwork: The tumor cell edition

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Science  04 Dec 2015:
Vol. 350, Issue 6265, pp. 1174-1175
DOI: 10.1126/science.aad7103

Figures

  • Wnt1 tumors with a biclonal organization require both subclones for tumor propagation.

    Tumors identified as containing genetically distinct luminal Wnt1high HRaswild-type and basal Wnt1low HRasmutant subclones were separated by fluorescence-activated cell sorting (FACS) into their component cell populations and then transplanted, either separately or as a 1:1 admixture, into mammary fat pads of wild-type host animals. Animals receiving either subclone alone failed to develop tumors, whereas the cell mixture containing both subclones was highly tumorigenic.

    ILLUSTRATION: C. BICKEL/SCIENCE
  • PHOTO: KENNETH SMITH, PENN STATE COLLEGE OF MEDICINE

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