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Science  04 Dec 2015:
Vol. 350, Issue 6265, pp. 1270
DOI: 10.1126/science.350.6265.1270-a

Cell Counter

The Cell Counter model R1 offers user-friendly and cost-effective cell counting for routine cell culturing. The R1 uses innovative liquid-lens autofocus technology, which mimics the way the human eye focuses. It features software with a unique algorithm for accurate, automated cell counts in as little as 15 seconds. The R1 is designed to be user friendly and includes a 7-inch touchscreen display with an intuitive interface. The software is easily optimized and features cell-size and roundness-based sorting capabilities, the ability to identify live and dead cells, clumped cell declustering, and an automatic dilution calculator. Users can easily adjust the minimum and maximum cell size so that only desired cells are detected. Counts can then be displayed as a histogram for analyzing certain cells based on size distribution. The R1 can store up to 1,000 counts and 300 different cell protocols, facilitating quick setup and counting for routine culturing procedures.

Mass Cytometry System

The CyTOF platform enables system-level biology at single-cell resolution, on an accessible, expandable system designed for breakthrough discovery. Mass cytometry has driven the revolution of single-cell proteomics, enabling the most comprehensive understanding of cell phenotypes, signaling pathways, and function. Helios is the most advanced tool for cellular exploration, with streamlined workflows and multimodal capabilities that can transform single-cell biology. The Helios platform delivers an extensive list of features and advances to the core CyTOF technology, enhancing performance and convenience of operation. These include a more intuitive and easy-to-use software interface with real-time data display, normalization, and control. Helios also provides improved sensitivity to detect and resolve lowerabundance targets and an expanded mass range of 135 discrete channels with virtually no signal overlap or background noise as compared to conventional techniques. This enables more comprehensive and straightforward panel designs and higher-quality data sets. 

Broadband Filter Sets

Three exciting new broadband filter sets that support Brilliant Violet and Ultraviolet dyes are now available. When used in conjunction with these 10× brighter dyes, the new filter sets allow microscopists to visualize molecules of small quantities or low expression within the cell. For laser applications, including flow cytometry, these new emission filters are designed to block common laser lines of 355 nm and 405 nm. The BUV395-3018A, BV421-3824A, and BV510-3825A sets are all available for purchase online and immediate shipment. All Semrock products carry their industry-leading 10-year warranty. All of the new BD Bioscience Brilliant dyes and Semrock filter products are available to test and model in SearchLight, the online toolbox that allows you to easily see all of the elements of your fluorescence system. SearchLight allows engineers and biologists alike to quickly calculate relative signal brightness, signal-to-noise ratio, and autofluoresence levels for best filter compatibility.

Fluorescence Illumination System

The new Lumen 1600-LED fluorescence illumination system is designed for the most advanced fluorescent techniques; however, it has intuitive controls making it easy to use. The light-emitting diodes (LEDs) in the Lumen 1600 last at least 25,000 hours and deliver evenly distributed, high-intensity light for optimal excitation of fluorophores. Incorporating 16 LEDs and covering the spectrum from 365 nm to 770 nm, the Lumen 1600 is an ideal illumination tool for work involving multiple fluorophores. Using an innovative four-channel system, the Lumen 1600 allows up to four distinct fluorophores to be excited simultaneously. These LED groupings allow the use of almost all stains used in multiband combinations, allowing great flexibility in experimental work. Multiple preset modes are possible, from simple white light illumination to more advanced options with different intensities of individual LED emissions. This flexibility makes the Lumen 1600 ideal for use by imaging facilities where multiple users with different requirements use the same equipment.

Cell Disruption Device

The Spiral Mill from Cellcrusher is a cooled-bead homogenizer for disrupting tough microorganisms. It is designed specifically for protein-scale work, accommodating 1–6 g samples. These samples are disrupted in reusable grinding chambers made of stainless steel to facilitate cooling. The unique cell-disruption process involves a rotating spiral inside the grinding chamber. In the narrow space between the spiral and the chamber wall, violent collisions occur between glass beads and cells, resulting in fast, effective cell lysis. The frictional heat generated by these collisions is conducted away through the steel chamber walls. Unlike those found in other bead homogenizers, the Spiral Mill's sample chamber does not move, because agitation is induced by the rotating spiral. This design facilitates an uncomplicated, reliable cooling system involving pumped ice water. The temperature remains around 2°C during processing. The novel chamber design and simple cooling system make the Spiral Mill the ideal device for disrupting mid-size samples of the toughest microorganisms.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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