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Rationally engineered Cas9 nucleases with improved specificity

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Science  01 Jan 2016:
Vol. 351, Issue 6268, pp. 84-88
DOI: 10.1126/science.aad5227

Article Information

vol. 351 no. 6268 84-88

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History: 
  • Received for publication September 24, 2015
  • Accepted for publication November 18, 2015
  • .

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Author Information

  1. Ian M. Slaymaker1,2,3,4,*,
  2. Linyi Gao1,4,*,
  3. Bernd Zetsche1,2,3,4,
  4. David A. Scott1,2,3,4,
  5. Winston X. Yan1,5,6,
  6. Feng Zhang1,2,3,4,
  1. 1Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  2. 2McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  3. 3Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  4. 4Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  5. 5Graduate Program in Biophysics, Harvard Medical School, Boston, MA 02115, USA.
  6. 6Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.
  1. Corresponding author. E-mail: zhang{at}broadinstitute.org
  1. * These authors contributed equally to this work.

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