The 5300-year-old Helicobacter pylori genome of the Iceman

Frank Maixner; Ben Krause-Kyora; Dmitrij Turaev; Alexander Herbig; Michael R. Hoopmann; Janice L. Hallows; Ulrike Kusebauch; Eduard Egarter Vigl; Peter Malfertheiner; Francis Megraud; Niall O’Sullivan; Giovanna Cipollini; Valentina Coia; Marco Samadelli; Lars Engstrand; Bodo Linz; Robert L. Moritz; Rudolf Grimm; Johannes Krause; Almut Nebel; Yoshan Moodley; Thomas Rattei; Albert Zink

doi:10.1126/science.aad2545

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The 5300-year-old Helicobacter pylori genome of the Iceman

Frank Maixner¹,*,†,
Ben Krause-Kyora²,†,
Dmitrij Turaev³,†,
Alexander Herbig⁴,⁵,†,
Michael R. Hoopmann⁶,
Janice L. Hallows⁶,
Ulrike Kusebauch⁶,
Eduard Egarter Vigl⁷,
Peter Malfertheiner⁸,
Francis Megraud⁹,
Niall O’Sullivan¹,
Giovanna Cipollini¹,
Valentina Coia¹,
Marco Samadelli¹,
Lars Engstrand¹⁰,
Bodo Linz¹¹,
Robert L. Moritz⁶,
Rudolf Grimm¹²,
Johannes Krause⁴,⁵,‡,
Almut Nebel²,‡,
Yoshan Moodley¹³,¹⁴,‡,
Thomas Rattei³,‡,
Albert Zink¹,*,‡

¹Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.
²Institute of Clinical Molecular Biology, Kiel University, Schittenhelmstrasse 12, 24105 Kiel, Germany.
³CUBE–Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.
⁴Institute for Archaeological Sciences, University of Tübingen, Rümelinstrasse 23, 72072 Tübingen, Germany.
⁵Max Planck Institute for the Science of Human History, Kahlaische Strasse 10, 07745 Jena, Germany.
⁶Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.
⁷Scuola Superiore Sanitaria Provinciale “Claudiana,” Via Lorenz Böhler 13, 39100 Bolzano, Italy.
⁸Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany.
⁹Université de Bordeaux, Centre National de Référence des Helicobacters et Campylobacters and INSERM U853, 146 rue Léo Saignat, 33076 Bordeaux, France.
¹⁰Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 141 83 Stockholm, Sweden.
¹¹Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA.
¹²Robert Mondavi Institute for Food Science, University of California, Davis, CA 95616, USA.
¹³Department of Zoology, University of Venda, Private Bag X5050, Thohoyandou 0950, Republic of South Africa.
¹⁴Department of Integrative Biology and Evolution, Konrad Lorenz Institute for Ethology, University of Veterinary Medicine Vienna, Savoyenstrasse 1a, 1160 Vienna, Austria.

↵*Corresponding author. E-mail: frank.maixner{at}eurac.edu (F.M.); albert.zink{at}eurac.edu (A.Z.)

↵† These authors contributed equally to this work.
↵‡ These authors contributed equally to this work.

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Science 08 Jan 2016:
Vol. 351, Issue 6269, pp. 162-165
DOI: 10.1126/science.aad2545

Frank Maixner

1Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

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For correspondence: frank.maixner@eurac.edu albert.zink@eurac.edu

Ben Krause-Kyora

2Institute of Clinical Molecular Biology, Kiel University, Schittenhelmstrasse 12, 24105 Kiel, Germany.

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Dmitrij Turaev

3CUBE–Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.

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Alexander Herbig

4Institute for Archaeological Sciences, University of Tübingen, Rümelinstrasse 23, 72072 Tübingen, Germany.

5Max Planck Institute for the Science of Human History, Kahlaische Strasse 10, 07745 Jena, Germany.

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Michael R. Hoopmann

6Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.

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Janice L. Hallows

6Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.

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Ulrike Kusebauch

6Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.

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Eduard Egarter Vigl

7Scuola Superiore Sanitaria Provinciale “Claudiana,” Via Lorenz Böhler 13, 39100 Bolzano, Italy.

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Peter Malfertheiner

8Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany.

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Francis Megraud

9Université de Bordeaux, Centre National de Référence des Helicobacters et Campylobacters and INSERM U853, 146 rue Léo Saignat, 33076 Bordeaux, France.

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Niall O’Sullivan

1Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

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Giovanna Cipollini

1Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

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Valentina Coia

1Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

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Marco Samadelli

1Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

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Lars Engstrand

10Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 141 83 Stockholm, Sweden.

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Bodo Linz

11Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA.

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Robert L. Moritz

6Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.

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Rudolf Grimm

12Robert Mondavi Institute for Food Science, University of California, Davis, CA 95616, USA.

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Johannes Krause

4Institute for Archaeological Sciences, University of Tübingen, Rümelinstrasse 23, 72072 Tübingen, Germany.

5Max Planck Institute for the Science of Human History, Kahlaische Strasse 10, 07745 Jena, Germany.

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Almut Nebel

2Institute of Clinical Molecular Biology, Kiel University, Schittenhelmstrasse 12, 24105 Kiel, Germany.

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Yoshan Moodley

13Department of Zoology, University of Venda, Private Bag X5050, Thohoyandou 0950, Republic of South Africa.

14Department of Integrative Biology and Evolution, Konrad Lorenz Institute for Ethology, University of Veterinary Medicine Vienna, Savoyenstrasse 1a, 1160 Vienna, Austria.

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Thomas Rattei

3CUBE–Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.

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Albert Zink

1Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

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For correspondence: frank.maixner@eurac.edu albert.zink@eurac.edu

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