The 5300-year-old Helicobacter pylori genome of the Iceman

Frank Maixner; Ben Krause-Kyora; Dmitrij Turaev; Alexander Herbig; Michael R. Hoopmann; Janice L. Hallows; Ulrike Kusebauch; Eduard Egarter Vigl; Peter Malfertheiner; Francis Megraud; Niall O’Sullivan; Giovanna Cipollini; Valentina Coia; Marco Samadelli; Lars Engstrand; Bodo Linz; Robert L. Moritz; Rudolf Grimm; Johannes Krause; Almut Nebel; Yoshan Moodley; Thomas Rattei; Albert Zink

doi:10.1126/science.aad2545

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The 5300-year-old Helicobacter pylori genome of the Iceman

Frank Maixner¹,*,†,
Ben Krause-Kyora²,†,
Dmitrij Turaev³,†,
Alexander Herbig⁴,⁵,†,
Michael R. Hoopmann⁶,
Janice L. Hallows⁶,
Ulrike Kusebauch⁶,
Eduard Egarter Vigl⁷,
Peter Malfertheiner⁸,
Francis Megraud⁹,
Niall O’Sullivan¹,
Giovanna Cipollini¹,
Valentina Coia¹,
Marco Samadelli¹,
Lars Engstrand¹⁰,
Bodo Linz¹¹,
Robert L. Moritz⁶,
Rudolf Grimm¹²,
Johannes Krause⁴,⁵,‡,
Almut Nebel²,‡,
Yoshan Moodley¹³,¹⁴,‡,
Thomas Rattei³,‡,
Albert Zink¹,*,‡

¹Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.
²Institute of Clinical Molecular Biology, Kiel University, Schittenhelmstrasse 12, 24105 Kiel, Germany.
³CUBE–Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.
⁴Institute for Archaeological Sciences, University of Tübingen, Rümelinstrasse 23, 72072 Tübingen, Germany.
⁵Max Planck Institute for the Science of Human History, Kahlaische Strasse 10, 07745 Jena, Germany.
⁶Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.
⁷Scuola Superiore Sanitaria Provinciale “Claudiana,” Via Lorenz Böhler 13, 39100 Bolzano, Italy.
⁸Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany.
⁹Université de Bordeaux, Centre National de Référence des Helicobacters et Campylobacters and INSERM U853, 146 rue Léo Saignat, 33076 Bordeaux, France.
¹⁰Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 141 83 Stockholm, Sweden.
¹¹Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA.
¹²Robert Mondavi Institute for Food Science, University of California, Davis, CA 95616, USA.
¹³Department of Zoology, University of Venda, Private Bag X5050, Thohoyandou 0950, Republic of South Africa.
¹⁴Department of Integrative Biology and Evolution, Konrad Lorenz Institute for Ethology, University of Veterinary Medicine Vienna, Savoyenstrasse 1a, 1160 Vienna, Austria.

↵*Corresponding author. E-mail: frank.maixner{at}eurac.edu (F.M.); albert.zink{at}eurac.edu (A.Z.)

↵† These authors contributed equally to this work.
↵‡ These authors contributed equally to this work.

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Science 08 Jan 2016:
Vol. 351, Issue 6269, pp. 162-165
DOI: 10.1126/science.aad2545

Frank Maixner

Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

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For correspondence: frank.maixner@eurac.edu albert.zink@eurac.edu

Ben Krause-Kyora

Institute of Clinical Molecular Biology, Kiel University, Schittenhelmstrasse 12, 24105 Kiel, Germany.

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Dmitrij Turaev

CUBE–Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.

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Alexander Herbig

Institute for Archaeological Sciences, University of Tübingen, Rümelinstrasse 23, 72072 Tübingen, Germany.Max Planck Institute for the Science of Human History, Kahlaische Strasse 10, 07745 Jena, Germany.

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Michael R. Hoopmann

Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.

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Janice L. Hallows

Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.

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Ulrike Kusebauch

Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.

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Eduard Egarter Vigl

Scuola Superiore Sanitaria Provinciale “Claudiana,” Via Lorenz Böhler 13, 39100 Bolzano, Italy.

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Peter Malfertheiner

Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany.

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Francis Megraud

Université de Bordeaux, Centre National de Référence des Helicobacters et Campylobacters and INSERM U853, 146 rue Léo Saignat, 33076 Bordeaux, France.

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Niall O’Sullivan

Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

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Giovanna Cipollini

Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

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Valentina Coia

Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

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Marco Samadelli

Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

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Lars Engstrand

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 141 83 Stockholm, Sweden.

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Bodo Linz

Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA.

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Robert L. Moritz

Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.

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Rudolf Grimm

Robert Mondavi Institute for Food Science, University of California, Davis, CA 95616, USA.

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Johannes Krause

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Almut Nebel

Institute of Clinical Molecular Biology, Kiel University, Schittenhelmstrasse 12, 24105 Kiel, Germany.

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Yoshan Moodley

Department of Zoology, University of Venda, Private Bag X5050, Thohoyandou 0950, Republic of South Africa.Department of Integrative Biology and Evolution, Konrad Lorenz Institute for Ethology, University of Veterinary Medicine Vienna, Savoyenstrasse 1a, 1160 Vienna, Austria.

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Thomas Rattei

CUBE–Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.

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Albert Zink

Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

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For correspondence: frank.maixner@eurac.edu albert.zink@eurac.edu

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