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Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

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Science  08 Jan 2016:
Vol. 351, Issue 6269, pp. 173-176
DOI: 10.1126/science.aad2033

Article Information

vol. 351 no. 6269 173-176

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History: 
  • Received for publication August 7, 2015
  • Accepted for publication November 11, 2015
  • .

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Author Information

  1. Andreas C. Woerner1,
  2. Frédéric Frottin1,
  3. Daniel Hornburg2,
  4. Li R. Feng1,*,
  5. Felix Meissner2,
  6. Maria Patra3,
  7. Jörg Tatzelt3,4,
  8. Matthias Mann2,5,
  9. Konstanze F. Winklhofer3,5,6,
  10. F. Ulrich Hartl1,5,,
  11. Mark S. Hipp1,5,
  1. 1Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
  2. 2Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
  3. 3Neurobiochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Schillerstr. 44, D-80336 Munich, Germany.
  4. 4Department of Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Universitätsstraße 150, D-44801 Bochum, Germany.
  5. 5Munich Cluster for Systems Neurology (SyNergy), D-80336 Munich, Germany.
  6. 6Department of Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Universitätsstraße 150, D-44801 Bochum, Germany.
  1. Corresponding author. E-mail: hipp{at}biochem.mpg.de (M.S.H.); uhartl{at}biochem.mpg.de (F.U.H.)
  • * Present address: National Institutes of Health, Bethesda, MD 20892, USA.

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