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Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

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Science  22 Jan 2016:
Vol. 351, Issue 6271, pp. 391-396
DOI: 10.1126/science.aad6780

Article Information

vol. 351 no. 6271 391-396

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History: 
  • Received for publication October 19, 2015
  • Accepted for publication December 10, 2015
  • .

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Author Information

  1. Upasna Sharma1,*,
  2. Colin C. Conine1,*,
  3. Jeremy M. Shea1,
  4. Ana Boskovic1,
  5. Alan G. Derr2,3,
  6. Xin Y. Bing1,
  7. Clemence Belleannee4,
  8. Alper Kucukural2,3,
  9. Ryan W. Serra1,
  10. Fengyun Sun1,
  11. Lina Song1,
  12. Benjamin R. Carone1,
  13. Emiliano P. Ricci5,,
  14. Xin Z. Li1,5,,
  15. Lucas Fauquier1,
  16. Melissa J. Moore1,5,6,
  17. Robert Sullivan4,
  18. Craig C. Mello2,5,6,
  19. Manuel Garber2,3,
  20. Oliver J. Rando1,§
  1. 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  2. 2Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  3. 3Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  4. 4Department of Obstetrics, Gynecology and Reproduction, Université Laval, Centre Hospitalier Universitaire de Québec Research Center, Quebec City, Quebec G1V 4G2, Canada.
  5. 5RNAi Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  6. 6Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  1. §Corresponding author. E-mail: oliver.rando{at}umassmed.edu
  1. * These authors contributed equally to this work.

  • Present address: INSERM U1111, Centre International de Recherche en Infectiologie, Ecole Normale Supérieure de Lyon, Université de Lyon, 69364 Lyon, France.

  • Present address: Center for RNA Biology: From Genome to Therapeutics, University of Rochester, Rochester, NY 14642, USA.

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