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Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction

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Science  29 Jan 2016:
Vol. 351, Issue 6272, pp. 514-516
DOI: 10.1126/science.aad1795

Replacing the Y chromosome

The mammalian Y chromosome encodes a specialized set of genes that are essential for male viability and fertility. In particular, the sex-determining region Y (SRY) protein is necessary to initiate male sex determination. However, Yamauchi et al. show that the functions of the entire Y chromosome can be replaced with only two genes. In mice, two transgenes, Sox9 and Eif2s3x, compensated for the absence of all Y chromosome genes to allow successful sperm formation.

Science, this issue p. 514

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