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Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

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Science  05 Feb 2016:
Vol. 351, Issue 6273, pp. 604-608
DOI: 10.1126/science.aad6204

Article Information

vol. 351 no. 6273 604-608

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History: 
  • Received for publication October 12, 2015
  • Accepted for publication January 6, 2016
  • .

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Author Information

  1. Piro Lito1,*,
  2. Martha Solomon2,
  3. Lian-Sheng Li3,
  4. Rasmus Hansen3,
  5. Neal Rosen1,2,*
  1. 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  2. 2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  3. 3Wellspring Biosciences, La Jolla, CA, USA.
  1. *Corresponding author. E-mail: rosenn{at}mskcc.org (N.R.); litop{at}mskcc.org (P.L.)

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