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Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling

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Science  19 Feb 2016:
Vol. 351, Issue 6275, pp. 849-854
DOI: 10.1126/science.aab3103

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Glial cell properties dictated by neurons

Neurons in the brain coexist with astrocytes, a type of glial cell, which help support many functions of their neighboring nerve cells. Farmer et al. now show that the support goes both ways (see the Perspective by Stevens and Muthukumar). They explored the influence of neurons on two specialized types of astrocytes in the mouse cerebellar cortex. The neurons produced the morphogen known as Sonic Hedgehog. Hedgehog signaling adjusted distinctive gene expression within the two astrocyte cell types. Thus, mature neurons appear to promote and maintain specific properties of associated astrocytes.

Science, this issue p. 849; see also p. 813