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Research Article
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
- Gloria B. Choi1,*,
- Yeong S. Yim1,*,
- Helen Wong2,3,*,
- Sangdoo Kim4,
- Hyunju Kim4,
- Sangwon V. Kim5,
- Charles A. Hoeffer2,3,†,
- Dan R. Littman5,6,†,
- Jun R. Huh4,5,†
- 1The McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 2Center for Neural Science, New York University, New York, NY 10003, USA.
- 3Institute for Behavioral Genetics, Department of Integrated Physiology, University of Colorado, Boulder, CO 80303, USA.
- 4Division of Infectious Diseases and Immunology and Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
- 5The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
- 6Howard Hughes Medical Institute, New York, NY 10016, USA.
- ↵†Corresponding author. E-mail: charles.hoeffer{at}colorado.edu (C.A.H.); dan.littman{at}med.nyu.edu (D.R.L.); jun.huh{at}umassmed.edu (J.R.H.)
↵* These authors contributed equally to this work.
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Science 26 Feb 2016:
Vol. 351, Issue 6276, pp. 933-939
DOI: 10.1126/science.aad0314
Vol. 351, Issue 6276, pp. 933-939
DOI: 10.1126/science.aad0314
Gloria B. Choi
1The McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Yeong S. Yim
1The McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Helen Wong
2Center for Neural Science, New York University, New York, NY 10003, USA.
3Institute for Behavioral Genetics, Department of Integrated Physiology, University of Colorado, Boulder, CO 80303, USA.
Sangdoo Kim
4Division of Infectious Diseases and Immunology and Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Hyunju Kim
4Division of Infectious Diseases and Immunology and Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Sangwon V. Kim
5The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
Charles A. Hoeffer
2Center for Neural Science, New York University, New York, NY 10003, USA.
3Institute for Behavioral Genetics, Department of Integrated Physiology, University of Colorado, Boulder, CO 80303, USA.
Dan R. Littman
5The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
6Howard Hughes Medical Institute, New York, NY 10016, USA.
Jun R. Huh
4Division of Infectious Diseases and Immunology and Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
5The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
