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Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

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Science  25 Mar 2016:
Vol. 351, Issue 6280, pp. 1463-1469
DOI: 10.1126/science.aaf1490

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vol. 351 no. 6280 1463-1469

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History: 
  • Received for publication December 24, 2015
  • Accepted for publication February 11, 2016

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Author Information

  1. Nicholas McGranahan1,2,3,*,
  2. Andrew J. S. Furness3,4,*,
  3. Rachel Rosenthal3,*,
  4. Sofie Ramskov5,
  5. Rikke Lyngaa5,
  6. Sunil Kumar Saini5,
  7. Mariam Jamal-Hanjani3,
  8. Gareth A. Wilson1,3,
  9. Nicolai J. Birkbak1,3,
  10. Crispin T. Hiley1,3,
  11. Thomas B. K. Watkins1,3,
  12. Seema Shafi3,
  13. Nirupa Murugaesu3,
  14. Richard Mitter1,
  15. Ayse U. Akarca4,6,
  16. Joseph Linares4,6,
  17. Teresa Marafioti4,6,
  18. Jake Y. Henry3,4,
  19. Eliezer M. Van Allen7,8,9,
  20. Diana Miao7,8,
  21. Bastian Schilling10,11,
  22. Dirk Schadendorf10,11,
  23. Levi A. Garraway7,8,9,
  24. Vladimir Makarov12,
  25. Naiyer A. Rizvi13,
  26. Alexandra Snyder14,15,
  27. Matthew D. Hellmann14,15,
  28. Taha Merghoub14,16,
  29. Jedd D. Wolchok14,15,16,
  30. Sachet A. Shukla7,8,
  31. Catherine J. Wu7,8,17,18,
  32. Karl S. Peggs3,4,
  33. Timothy A. Chan12,
  34. Sine R. Hadrup5,
  35. Sergio A. Quezada3,4,,
  36. Charles Swanton1,3,
  1. 1The Francis Crick Institute, London WC2A 3LY, UK.
  2. 2Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London (UCL), London WC1E 6BT, UK.
  3. 3Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK.
  4. 4Cancer Immunology Unit, UCL Cancer Institute, UCL, London WC1E 6BT, UK.
  5. 5Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark, 1970 Frederiksberg C, Denmark.
  6. 6Department of Cellular Pathology, UCL, London WC1E 6BT, UK.
  7. 7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  8. 8Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  9. 9Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  10. 10Department of Dermatology, University Hospital, University Duisburg–Essen, 45147 Essen, Germany.
  11. 11German Cancer Consortium (DKTK), 69121 Heidelberg, Germany.
  12. 12Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  13. 13Hematology/Oncology Division, 177 Fort Washington Avenue, Columbia University, New York, NY 10032, USA.
  14. 14Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  15. 15Weill Cornell Medical College, New York, NY 10065, USA.
  16. 16Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  17. 17Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  18. 18Department of Internal Medicine, Brigham and Woman’s Hospital, Boston, MA 02115, USA.
  1. Corresponding author. E-mail: s.quezada{at}ucl.ac.uk (S.A.Q.); charles.swanton{at}crick.ac.uk (C.S.)
  1. * These authors contributed equally to this work.

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