PerspectiveTissue Regeneration

A scaffold immune microenvironment

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Science  15 Apr 2016:
Vol. 352, Issue 6283, pp. 298
DOI: 10.1126/science.aaf7587

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The immune system plays a critical role in wound healing, in both host defense and tissue repair. Strategies that use biologic scaffolds to support tissue reconstruction emphasize this essential contribution of representative immune cells. The findings by Sadtler et al. (1) on page 366 in this issue highlight how the plasticity and diversity of macrophages and lymphocytes support this approach to tissue repair.