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Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

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Science  15 Apr 2016:
Vol. 352, Issue 6283, pp. 366-370
DOI: 10.1126/science.aad9272

Engineering a healing immune response

Infections, surgeries, and trauma can all cause major tissue damage. Biomaterial scaffolds, which help to guide regenerating tissue, are an exciting emerging therapeutic strategy to promote tissue repair. Sadtler et al. tested how biomaterial scaffolds interact with the immune system in damaged tissue to promote repair (see the Perspective by Badylak). Scaffolds derived from cardiac muscle and bone extracellular matrix components trigger a tissue-reparative T cell immune response in mice with injured muscles.

Science, this issue p. 366; see also p. 298

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