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Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

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Science  22 Apr 2016:
Vol. 352, Issue 6284, pp. 463-466
DOI: 10.1126/science.aaf3926

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  • Mice are valuable to study the impact of aging during IAV infection.
    • Daniel Goldstein, Principal Investigator, University of Michigan 2016-present, formerly of Yale School of Medicine

    The study by Pillai and colleagues reported that mice aged up to 24-30 months of age exhibit increased survival during influenza viral (IAV) infection with lower viral load in the lungs compared to young mice (2-4 months of age) (Supplemental Figure 3). These findings contrast with prior studies that found that aged mice die faster than young mice during IAV infection (Stout-Delgado et al., 2012; Zhao et al., 2011), and also our work that found that aged mice (24 months of age) exhibit increased mortality compared to young mice during IAV infection (Kulkarni et al., 2019; Wong et al., 2017). However, a recent study also found that aged mice displayed increased survival during IAV as compared to young mice (Lu et al., 2018). A distinguishing feature of the two studies that found that aged mice exhibit increased survival compared to young mice was the use of 20uL as the volume of viral inoculum, whereas the other studies, including our own, all used at least 40uL to deliver the virus intranasally (Stout-Delgado et al., 2012; Zhao et al., 2011; Kulkarni et al., 2019; Wong et al., 2017). To resolve the discrepancy between the studies, our recent report examined whether the volume of viral inoculum, specifically 20uL vs. 40uL, impacted mortality, viral load and the anti-viral cytokine (IFN-beta) levels between young and aged mice during IAV infection (Smith CA et al., 2019). We found that 40uL, but not 20uL, (both containing 1x104 PFU of virus) led to an age-dependent mortalit...

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    Competing Interests: None declared.

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