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Research Article
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
- Hongbo Zhang1,
- Dongryeol Ryu1,
- Yibo Wu2,
- Karim Gariani1,
- Xu Wang1,
- Peiling Luan1,
- Davide D’Amico1,
- Eduardo R. Ropelle1,3,
- Matthias P. Lutolf4,
- Ruedi Aebersold2,5,
- Kristina Schoonjans6,
- Keir J. Menzies1,7,*,
- Johan Auwerx1,*
- 1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
- 2Department of Biology, Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zürich (ETHZ), 8093 Zurich, Switzerland.
- 3Laboratory of Molecular Biology of Exercise, School of Applied Science, University of Campinas, CEP 13484-350 Limeira, São Paulo, Brazil.
- 4Laboratory of Stem Cell Bioengineering, EPFL, 1015 Lausanne, Switzerland.
- 5Faculty of Science, University of Zurich, 8057 Zurich, Switzerland.
- 6Metabolic Signaling, EPFL, 1015 Lausanne, Switzerland.
- 7Interdisciplinary School of Health Sciences, University of Ottawa Brain and Mind Research Institute, 451 Smyth Road, K1H 8M5 Ottawa, Ontario, Canada.
- ↵*Corresponding author. Email: kmenzies{at}uottawa.ca (K.J.M.); admin.auwerx{at}epfl.ch (J.A.)
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Science 17 Jun 2016:
Vol. 352, Issue 6292, pp. 1436-1443
DOI: 10.1126/science.aaf2693
Vol. 352, Issue 6292, pp. 1436-1443
DOI: 10.1126/science.aaf2693
Hongbo Zhang
1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Dongryeol Ryu
1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Yibo Wu
2Department of Biology, Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zürich (ETHZ), 8093 Zurich, Switzerland.
Karim Gariani
1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Xu Wang
1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Peiling Luan
1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Davide D’Amico
1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Eduardo R. Ropelle
1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
3Laboratory of Molecular Biology of Exercise, School of Applied Science, University of Campinas, CEP 13484-350 Limeira, São Paulo, Brazil.
Matthias P. Lutolf
4Laboratory of Stem Cell Bioengineering, EPFL, 1015 Lausanne, Switzerland.
Ruedi Aebersold
2Department of Biology, Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zürich (ETHZ), 8093 Zurich, Switzerland.
5Faculty of Science, University of Zurich, 8057 Zurich, Switzerland.
Kristina Schoonjans
6Metabolic Signaling, EPFL, 1015 Lausanne, Switzerland.
Keir J. Menzies
1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
7Interdisciplinary School of Health Sciences, University of Ottawa Brain and Mind Research Institute, 451 Smyth Road, K1H 8M5 Ottawa, Ontario, Canada.
Johan Auwerx
1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
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