NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Hongbo Zhang; Dongryeol Ryu; Yibo Wu; Karim Gariani; Xu Wang; Peiling Luan; Davide D’Amico; Eduardo R. Ropelle; Matthias P. Lutolf; Ruedi Aebersold; Kristina Schoonjans; Keir J. Menzies; Johan Auwerx

doi:10.1126/science.aaf2693

Research Article

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

Hongbo Zhang¹,
Dongryeol Ryu¹,
Yibo Wu²,
Karim Gariani¹,
Xu Wang¹,
Peiling Luan¹,
Davide D’Amico¹,
Eduardo R. Ropelle¹,³,
Matthias P. Lutolf⁴,
Ruedi Aebersold²,⁵,
Kristina Schoonjans⁶,
Keir J. Menzies¹,⁷,*,
Johan Auwerx¹,*

¹Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
²Department of Biology, Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zürich (ETHZ), 8093 Zurich, Switzerland.
³Laboratory of Molecular Biology of Exercise, School of Applied Science, University of Campinas, CEP 13484-350 Limeira, São Paulo, Brazil.
⁴Laboratory of Stem Cell Bioengineering, EPFL, 1015 Lausanne, Switzerland.
⁵Faculty of Science, University of Zurich, 8057 Zurich, Switzerland.
⁶Metabolic Signaling, EPFL, 1015 Lausanne, Switzerland.
⁷Interdisciplinary School of Health Sciences, University of Ottawa Brain and Mind Research Institute, 451 Smyth Road, K1H 8M5 Ottawa, Ontario, Canada.

↵*Corresponding author. Email: kmenzies{at}uottawa.ca (K.J.M.); admin.auwerx{at}epfl.ch (J.A.)

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Science 17 Jun 2016:
Vol. 352, Issue 6292, pp. 1436-1443
DOI: 10.1126/science.aaf2693

Hongbo Zhang

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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Dongryeol Ryu

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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Yibo Wu

Department of Biology, Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zürich (ETHZ), 8093 Zurich, Switzerland.

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Karim Gariani

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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Xu Wang

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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Peiling Luan

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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Davide D’Amico

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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Eduardo R. Ropelle

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Laboratory of Molecular Biology of Exercise, School of Applied Science, University of Campinas, CEP 13484-350 Limeira, São Paulo, Brazil.

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Matthias P. Lutolf

Laboratory of Stem Cell Bioengineering, EPFL, 1015 Lausanne, Switzerland.

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Ruedi Aebersold

Department of Biology, Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zürich (ETHZ), 8093 Zurich, Switzerland.

Faculty of Science, University of Zurich, 8057 Zurich, Switzerland.

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Kristina Schoonjans

Metabolic Signaling, EPFL, 1015 Lausanne, Switzerland.

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Keir J. Menzies

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Interdisciplinary School of Health Sciences, University of Ottawa Brain and Mind Research Institute, 451 Smyth Road, K1H 8M5 Ottawa, Ontario, Canada.

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For correspondence: kmenzies@uottawa.ca admin.auwerx@epfl.ch

Johan Auwerx

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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For correspondence: kmenzies@uottawa.ca admin.auwerx@epfl.ch

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NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

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