Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics

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Science  24 Jun 2016:
Vol. 352, Issue 6293, pp. 1533
DOI: 10.1126/science.aad9359


  • The concept that impaired postnatal gut microbiota development (maturation) is causally related to childhood undernutrition.

    The representation of age-discriminatory bacterial taxa defines a program of normal gut microbiota development. Disrupting the coordinated functional codevelopment of microbiota and host affects multiple biological regulatory systems through largely unknown mechanisms. Developing effective strategies for sustained repair of microbiota immaturity though food or microbial interventions requires preclinical studies of these mechanisms and modeling of the effects of different rates and routes of repair.

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