22 July 2016
Vol 353, Issue 6297

About The Cover

Cover image expansion

COVER Computationally designed, 120-subunit icosahedral protein nanoparticles (yellow, dimers; blue, trimers; green, pentamers). Combinations of these shapes result in a kaleidoscopic array of self-assembling protein complexes, each of which rivals the size of a small viral capsid. Protein assemblies like these could form the basis for a new generation of biomolecular machines with structures and functions that are customizable for particular applications. See pages 338 and 389.
Illustration: Valerie Altounian/Science, based on design models provided by J. Bale