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Science  12 Aug 2016:
Vol. 353, Issue 6300, pp. 713
DOI: 10.1126/science.353.6300.713

Confocal Laser Scanning Microscope

Zeiss introduces the LSM 800 confocal laser scanning microscope for materials applications and analysis in research and industry. The LSM 800 enables precise, 3D imaging of microstructures and surfaces. The combination of confocal fluorescence and other contrasting techniques [brightfield, darkfield, polarization, and Zeiss's unique Circular Differential Interference Contrast (C-DIC)] in one instrument enables high-precision examination of nanomaterials, metals, polymers, and semiconductors with maximum information content. The system offers precise capture of 3D topography and the investigation of nanometer-scale structures without causing surface damage. The combination of the LSM 800 laser scanning module with Zeiss's Axio Imager enables a wide variety of configurations in hardware, for example, objectives, stages, and illumination. The LSM 800 comes with the newest version of Zeiss Efficient Navigation (ZEN) imaging software, which includes an open application development interface for data exchange with established third-party analysis and research software.

FT-NIR Spectrometer

For small business owners, technicians, laboratory managers, and method developers, a new Fourier transform-near infrared (FT-NIR) spectrometer is designed to bring rapid and reliable analysis for quality control and material verification. The Thermo Scientific Nicolet iS5N FT-NIR spectrometer uses the same proprietary software platform found across the entire Nicolet FTIR spectroscopy family. The OMNIC Lite software supports routine system operation, and the TQ Analyst EZ or Pro software can be used for calibration model development. Users manage and customize workflows within the intuitive graphic user interface provided by the OMNIC software suite, which includes Macros Basic and Macros Pro. FT-NIR is a workhorse technique for materials identification and quality control. A reliable, cost-effective material analysis tool designed to meet the needs of busy labs, the Nicolet iS5N is set to extend NIR technology and proven IR analysis into new arenas.

ddPCR Multiplex Mutation Screening Kit

Five Droplet Digital PCR (ddPCR) Multiplex Mutation Screening Kits are available (KRAS Q61, NRAS G12, NRAS G12/G13, NRAS Q61, and BRAF V600) for detecting several key actionable cancer mutations and the wild-type allele in a single reaction. The combination of ddPCR and multiplexing technologies increases the throughput of genetic analysis and allows clinical researchers to connect specific genetic alterations with diagnosis, treatment efficacy, and disease recurrence. A test-to-result turnaround time can be seen within 72 hours. Sample partitioning in ddPCR enables the detection of rare nucleic acid sequences in a complex background of competing sequences, while minimizing the effect of inhibitory substances. The kits identify mutations present at allelic frequencies at or below 0.5%, making them ideal for use with FFPE and liquid biopsy samples. Their precision and sensitivity also enable early detection of important biomarkers.

Bioinformatics Software

The BaseSpace Informatics Suite accelerates genomic data analysis for sequence labs. It is the first cloud-based, sample-to-answer informatics infrastructure to enable precision medicine and genomics research. The integrated informatics solution enables users to engage with a unified, comprehensive platform, from laboratory information management, analysis, and sharing to sample interpretation, reporting, and advanced cohort analytics. The BaseSpace Suite reduces the time from sample submission to answer. It improves the overall accuracy of results without the need to integrate point solutions from multiple vendors, and is ideal for numerous labs, including clinical and translational labs and research institutions. The BaseSpace Suite is built to be cloud-ready, providing a secure, scalable solution, simplifying data storage issues, and providing a highly collaborative environment. The system provides preconfigured and customizable workflows and analysis pipelines. The platform is intuitive and user-friendly for a myriad of clients—from the clinical scientist to the lab director and researcher.

Carbon/Sulfur Analyzers

The EMIA-Pro and Expert carbon/sulfur analyzers offer nondispersive infrared (NDIR) measurement capabilities, optimizing their range from 1.6 ppm to 6.0% for carbon, and 2 ppm to 1.0% for sulfur. Equipped with a unique carbon monoxide detector, the analyzers can be used for a wide variety of inorganic materials such as steel, cokes, catalysts, nonferrous alloys like aluminum, and lithium-ion battery materials. A new cleaning mechanism allows increased cleaning efficiency compared to that of conventional carbon/sulfur analyzers. This mechanism enables users to repeat their measurements up to 200 times, with less time spent for maintenance and cleaning. A new, robust design with fewer components enables more reliable use and less service requirements. The EMIA-Pro and Expert offer increased measurement efficiency, with measurement, display of results, and cleaning taking about 70 seconds. They are also equipped with a navigation system that recommends the most suitable conditions for samples, troubleshoots errors, and alerts users to perform maintenance.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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