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Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

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Science  09 Sep 2016:
Vol. 353, Issue 6304, pp. 1161-1165
DOI: 10.1126/science.aaf5171

Article Information

vol. 353 no. 6304 1161-1165

PubMed: 
Print ISSN: 
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History: 
  • Received for publication February 21, 2016
  • Accepted for publication July 29, 2016
  • .

Author Information

  1. Jared R. Mayers1,2,*,
  2. Margaret E. Torrence1,2,*,
  3. Laura V. Danai1,
  4. Thales Papagiannakopoulos1,,
  5. Shawn M. Davidson1,2,
  6. Matthew R. Bauer1,
  7. Allison N. Lau1,
  8. Brian W. Ji3,
  9. Purushottam D. Dixit3,
  10. Aaron M. Hosios1,2,
  11. Alexander Muir1,
  12. Christopher R. Chin1,
  13. Elizaveta Freinkman1,2,4,5,6,
  14. Tyler Jacks1,2,6,
  15. Brian M. Wolpin7,
  16. Dennis Vitkup3,
  17. Matthew G. Vander Heiden1,2,5,7,
  1. 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  2. 2Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  3. 3Center for Computational Biology and Bioinformatics and Department of Systems Biology, Columbia University, New York, NY 10027, USA.
  4. 4Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  5. 5Broad Institute, Seven Cambridge Center, Cambridge, MA 02142, USA.
  6. 6Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  7. 7Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  8. *These authors contributed equally to this work.
  1. Corresponding author. Email: mvh{at}mit.edu
  • Present address: School of Medicine, New York University, New York, NY 10016, USA.

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