Specification of tissue-resident macrophages during organogenesis

Elvira Mass; Ivan Ballesteros; Matthias Farlik; Florian Halbritter; Patrick Günther; Lucile Crozet; Christian E. Jacome-Galarza; Kristian Händler; Johanna Klughammer; Yasuhiro Kobayashi; Elisa Gomez-Perdiguero; Joachim L. Schultze; Marc Beyer; Christoph Bock; Frederic Geissmann

doi:10.1126/science.aaf4238

Research Article

Specification of tissue-resident macrophages during organogenesis

Elvira Mass¹,*,
Ivan Ballesteros¹,*,
Matthias Farlik²,*,
Florian Halbritter²,*,
Patrick Günther³,*,
Lucile Crozet¹,⁴,
Christian E. Jacome-Galarza¹,
Kristian Händler³,
Johanna Klughammer²,
Yasuhiro Kobayashi⁵,
Elisa Gomez-Perdiguero⁶,†,
Joachim L. Schultze³,⁷,
Marc Beyer³,⁷,‡,
Christoph Bock²,⁸,⁹,‡,
Frederic Geissmann¹,⁴,⁶,‡,§

¹Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.
²CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
³Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
⁴Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
⁵Institute for Oral Science, Matsumoto Dental University, 1780 Hiro-Oka Gobara Shiojiri, Nagano 390-0781, Japan.
⁶Centre for Molecular and Cellular Biology of Inflammation, King’s College London, London SE1 1UL, UK.
⁷Single Cell Genomics and Epigenomics Unit at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
⁸Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
⁹Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

↵§Corresponding author. Email: geissmaf{at}mskcc.org

↵* These authors contributed equally to this work.
↵‡ These authors contributed equally to this work.

↵† Present address: Macrophages and Endothelial Cells Group, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, Paris, France.

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Science 09 Sep 2016:
Vol. 353, Issue 6304, aaf4238
DOI: 10.1126/science.aaf4238

Elvira Mass

1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

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Ivan Ballesteros

1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

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Matthias Farlik

2CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

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Florian Halbritter

2CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

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Patrick Günther

3Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

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Lucile Crozet

1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

4Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.

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Christian E. Jacome-Galarza

1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

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Kristian Händler

3Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

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Johanna Klughammer

2CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

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Yasuhiro Kobayashi

5Institute for Oral Science, Matsumoto Dental University, 1780 Hiro-Oka Gobara Shiojiri, Nagano 390-0781, Japan.

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Elisa Gomez-Perdiguero

6Centre for Molecular and Cellular Biology of Inflammation, King’s College London, London SE1 1UL, UK.

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Joachim L. Schultze

3Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

7Single Cell Genomics and Epigenomics Unit at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.

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Marc Beyer

3Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

7Single Cell Genomics and Epigenomics Unit at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.

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Christoph Bock

2CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

8Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.

9Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

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Frederic Geissmann

1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

4Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.

6Centre for Molecular and Cellular Biology of Inflammation, King’s College London, London SE1 1UL, UK.

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For correspondence: geissmaf@mskcc.org

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