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Research Article
Specification of tissue-resident macrophages during organogenesis
- Elvira Mass1,*,
- Ivan Ballesteros1,*,
- Matthias Farlik2,*,
- Florian Halbritter2,*,
- Patrick Günther3,*,
- Lucile Crozet1,4,
- Christian E. Jacome-Galarza1,
- Kristian Händler3,
- Johanna Klughammer2,
- Yasuhiro Kobayashi5,
- Elisa Gomez-Perdiguero6,†,
- Joachim L. Schultze3,7,
- Marc Beyer3,7,‡,
- Christoph Bock2,8,9,‡,
- Frederic Geissmann1,4,6,‡,§
- 1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.
- 2CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
- 3Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
- 4Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
- 5Institute for Oral Science, Matsumoto Dental University, 1780 Hiro-Oka Gobara Shiojiri, Nagano 390-0781, Japan.
- 6Centre for Molecular and Cellular Biology of Inflammation, King’s College London, London SE1 1UL, UK.
- 7Single Cell Genomics and Epigenomics Unit at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
- 8Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
- 9Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.
- ↵§Corresponding author. Email: geissmaf{at}mskcc.org
↵* These authors contributed equally to this work.
↵‡ These authors contributed equally to this work.
↵† Present address: Macrophages and Endothelial Cells Group, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, Paris, France.
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Science 09 Sep 2016:
Vol. 353, Issue 6304, aaf4238
DOI: 10.1126/science.aaf4238
Vol. 353, Issue 6304, aaf4238
DOI: 10.1126/science.aaf4238
Elvira Mass
1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.
Ivan Ballesteros
1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.
Matthias Farlik
2CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Florian Halbritter
2CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Patrick Günther
3Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
Lucile Crozet
1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.
4Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
Christian E. Jacome-Galarza
1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.
Kristian Händler
3Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
Johanna Klughammer
2CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Yasuhiro Kobayashi
5Institute for Oral Science, Matsumoto Dental University, 1780 Hiro-Oka Gobara Shiojiri, Nagano 390-0781, Japan.
Elisa Gomez-Perdiguero
6Centre for Molecular and Cellular Biology of Inflammation, King’s College London, London SE1 1UL, UK.
Joachim L. Schultze
3Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
7Single Cell Genomics and Epigenomics Unit at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
Marc Beyer
3Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
7Single Cell Genomics and Epigenomics Unit at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
Christoph Bock
2CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
8Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
9Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.
Frederic Geissmann
1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.
4Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
6Centre for Molecular and Cellular Biology of Inflammation, King’s College London, London SE1 1UL, UK.
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