Specification of tissue-resident macrophages during organogenesis

Elvira Mass; Ivan Ballesteros; Matthias Farlik; Florian Halbritter; Patrick Günther; Lucile Crozet; Christian E. Jacome-Galarza; Kristian Händler; Johanna Klughammer; Yasuhiro Kobayashi; Elisa Gomez-Perdiguero; Joachim L. Schultze; Marc Beyer; Christoph Bock; Frederic Geissmann

doi:10.1126/science.aaf4238

Research Article

Specification of tissue-resident macrophages during organogenesis

Elvira Mass¹,*,
Ivan Ballesteros¹,*,
Matthias Farlik²,*,
Florian Halbritter²,*,
Patrick Günther³,*,
Lucile Crozet¹,⁴,
Christian E. Jacome-Galarza¹,
Kristian Händler³,
Johanna Klughammer²,
Yasuhiro Kobayashi⁵,
Elisa Gomez-Perdiguero⁶,†,
Joachim L. Schultze³,⁷,
Marc Beyer³,⁷,‡,
Christoph Bock²,⁸,⁹,‡,
Frederic Geissmann¹,⁴,⁶,‡,§

¹Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.
²CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
³Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
⁴Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
⁵Institute for Oral Science, Matsumoto Dental University, 1780 Hiro-Oka Gobara Shiojiri, Nagano 390-0781, Japan.
⁶Centre for Molecular and Cellular Biology of Inflammation, King’s College London, London SE1 1UL, UK.
⁷Single Cell Genomics and Epigenomics Unit at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
⁸Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
⁹Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

↵§Corresponding author. Email: geissmaf{at}mskcc.org

↵* These authors contributed equally to this work.
↵‡ These authors contributed equally to this work.

↵† Present address: Macrophages and Endothelial Cells Group, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, Paris, France.

See allHide authors and affiliations

Science 09 Sep 2016:
Vol. 353, Issue 6304, aaf4238
DOI: 10.1126/science.aaf4238

Elvira Mass

Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ivan Ballesteros

Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Matthias Farlik

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Florian Halbritter

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Patrick Günther

Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Lucile Crozet

Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christian E. Jacome-Galarza

Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kristian Händler

Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Johanna Klughammer

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yasuhiro Kobayashi

Institute for Oral Science, Matsumoto Dental University, 1780 Hiro-Oka Gobara Shiojiri, Nagano 390-0781, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Elisa Gomez-Perdiguero

Centre for Molecular and Cellular Biology of Inflammation, King’s College London, London SE1 1UL, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Joachim L. Schultze

Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.Single Cell Genomics and Epigenomics Unit at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Marc Beyer

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christoph Bock

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Frederic Geissmann

Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.Centre for Molecular and Cellular Biology of Inflammation, King’s College London, London SE1 1UL, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: geissmaf@mskcc.org

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. eLetters are not edited, proofread, or indexed. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Specification of tissue-resident macrophages during organogenesis

Plain text

Vertical Tabs

Science

Article Tools