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A disynaptic feedback network activated by experience promotes the integration of new granule cells

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Science  28 Oct 2016:
Vol. 354, Issue 6311, pp. 459-465
DOI: 10.1126/science.aaf2156

Integration of adult-born brain cells

Physical exercise or exploration of a novel environment greatly influences the production, maturation, and connectivity of adult-born neurons. Alvarez et al. investigated how experience affects the incorporation of adult-born neurons into the hippocampal network. A brief period of sensory enrichment when new neurons were 9 to 10 days old led to neurons having larger dendrites and more functional spine synapses. A disynaptic preexisting feedback circuit promoted the growth and integration of the new cells.

Science, this issue p. 459

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