Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing

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Science  28 Oct 2016:
Vol. 354, Issue 6311, pp. 468-472
DOI: 10.1126/science.aae0047

Plunging into a domain of silence

Female mammals have two X chromosomes. One must be silenced to “balance” gene dosage with male XY cells. The Xist long noncoding RNA coats the inactive X chromosome in female mammalian cells. Chen et al. show that the Xist RNA helps recruit the X chromosome to the internal rim of the cell nucleus, a region where gene expression is silenced. Xist is recruited to the domain through an interaction with the Lamin B receptor. This recruitment allows the Xist RNA to spread across the future inactive X chromosome, shutting down gene expression.

Science, this issue p. 468

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