Senescent intimal foam cells are deleterious at all stages of atherosclerosis

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Science  28 Oct 2016:
Vol. 354, Issue 6311, pp. 472-477
DOI: 10.1126/science.aaf6659

Wreaking havoc while (growth-)arrested

Cells enter a state of senescence in response to certain stresses. Studying mouse models, Childs et al. examined the role of senescent lipid-loaded macrophages (so-called “foam cells”) in the pathogenesis of atherosclerosis. At early stages of atherosclerosis, senescent foam cells promoted the expression of inflammatory cytokines. At later stages, they promoted the expression of matrix metalloproteases implicated in the rupture of atherosclerotic plaque, which can lead to blood clots. Experimental removal of the senescent cells had beneficial effects at both stages of the disease.

Science, this issue p. 472

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