Research Articles

Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER

See allHide authors and affiliations

Science  28 Oct 2016:
Vol. 354, Issue 6311, aaf3928
DOI: 10.1126/science.aaf3928

A dynamic view of the endoplasmic reticulum

The endoplasmic reticulum (ER) is a complex membranous structure that extends from the nuclear envelope to the cell periphery. It has important roles in many cellular processes, and numerous proteins are involved in maintaining its structure. Nixon-Abell et al. used superresolution approaches to look at the ER at the periphery of the cell, where the ER contacts many other cellular organelles (see the Perspective by Terasaki). This peripheral ER has been thought to comprise tubules and sheets; however, the higher-resolution view revealed that most of the “sheets” consist of a dense clustering of tubules. This dynamic meshwork may allow the ER to change its conformation rapidly in response to cellular needs.

Science, this issue p. 433; see also p. 415

View Full Text