Contents
04 November 2016
Vol 354, Issue 6312
Vol 354, Issue 6312
Special Issue
Pain Research
Introduction to special issue
News
- Pot and pain
Hints are emerging that cannabis could be an alternative to opioid painkillers
PAIN RESEARCH
Reviews
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Sea ice shrinks in step with carbon emissions
Models may underestimate the pace of ice loss because they are missing Arctic warming
- Ambitious web fundraising startup fails to meet big goals
Hundreds of scientists paid fees to have their work featured on Benefunder, but very few received donations
- Controversial HIV vaccine strategy gets a second chance
Modest success in Thailand inspires South Africa trial
- ‘Four-legged snake’ may be ancient lizard instead
Controversy swirls around fossil, which is no longer accessible
- Data Check: California rules U.S. corporate research
New NSF survey finds that California has widened its lead over the rest of the country in state-by-state analysis of what companies spend on research.
Feature
- Mice made easy
The genome-editing tool CRISPR upends the vital business of creating mutant mice
- A reporter does CRISPR
Can “any idiot” succeed at using this powerful new genome-editing tool?
Working Life
Letters
Books et al.
Essays on Science and Society
- One brain, many genomes
Single-cell genomic techniques shed light on somatic mutations in brain development and neurologic disorders
- Parsing reward from aversion
Investigating the neural circuits encoding emotional valence
- Building connections
Studies in the developing retina provide insights into neural circuit assembly
Policy Forum
- Water strategies for the next administration
Water policy offers opportunity for nonpartisan agreement
Perspectives
- Building bridges to regenerate axons
A secreted factor stimulates glia to mend spinal cord injury
- A testing time for antimatter
Precision measurement of antiprotonic helium provides a test of physical laws
- Migratory birds under threat
Habitat degradation and loss, illegal killings, and climate change threaten European migratory bird populations
- How tobacco smoke changes the (epi)genome
Distinct mutation types are found in diverse cancers associated with smoking
- Deep-sea corals feel the flow
Uranium isotope data from deep-water corals help to resolve conflicting results from shallow-water corals
- Tips for battling billion-dollar beetles
Tiny insecticidal proteins (Tips) kill pests that evolved resistance to engineered corn
- A radical approach to posttranslational mutagenesis
Introducing diverse protein side chains via carbon-carbon bond-forming reactions
Research Articles
- Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity
Radical chemistry allows for the selective chemical modification of a range of proteins.
- Quantifying the evolution of individual scientific impact
Productivity, ability, and luck are incorporated into an algorithm describing a scientist’s impact.
- A transcription factor hierarchy defines an environmental stress response network
The response to the abscisic acid hormone in the model plant Arabidopsis involves complex transcription factor dynamics.
- Exploring genetic suppression interactions on a global scale
A large-scale study in yeast reveals how defects associated with a mutation in one gene can be compensated for by a second mutation in a suppressor gene.
Review
Reports
- Microresonator soliton dual-comb spectroscopy
Dual-comb spectroscopy is demonstrated using a pair of silica microresonators.
- A coherent Ising machine for 2000-node optimization problems
An optical-based processor is developed to solve a broad class of complex optimization problems.
- Universal space-time scaling symmetry in the dynamics of bosons across a quantum phase transition
The dynamics of a gas of cesium atoms in a shaken optical lattice follows a universality hypothesis.
- Buffer-gas cooling of antiprotonic helium to 1.5 to 1.7 K, and antiproton-to–electron mass ratio
Spectroscopy of a cold exotic molecule yields a precise value of the antiproton mass relative to the mass of the electron.
- A fully programmable 100-spin coherent Ising machine with all-to-all connections
An optical-based processor is developed to solve a broad class of complex optimization problems.
- Mutational signatures associated with tobacco smoking in human cancer
Tobacco smoke causes cancer through mutational processes that are more complex than previously thought.
- A chemical biology route to site-specific authentic protein modifications
Radical chemistry mediated by metal ions allows for the selective chemical modification of a range of proteins.
- Ocean mixing and ice-sheet control of seawater 234U/238U during the last deglaciation
The 234U/238U ratios of deep-sea corals illuminate glacially driven changes of the past 30,000 years.
- Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish
A connective tissue growth factor underlies the unusual regenerative capacity of the zebrafish central nervous system.
- A selective insecticidal protein from Pseudomonas for controlling corn rootworms
Corn can be engineered to produce an insecticidal peptide that protects the host plant from specific crop pests, leaving other insects unharmed.
From the AAAS Office of Publishing and Member Services
About The Cover
COVER A woman holds her hand in ice water, one of several techniques used to measure pain tolerance. Typically, healthy people can submerge their hands for up to 5 minutes. However, for some of those taking opioids, 10 to 15 seconds is the limit, suggesting opioid-induced hypersensitivity to pain. For more on recent developments in pain research, see the special section beginning on page 564
Photo: Matthew Rakola
