Editors' ChoiceCell Biology

Getting an UPR hand on recovERy

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Science  02 Dec 2016:
Vol. 354, Issue 6316, pp. 1115-1116
DOI: 10.1126/science.354.6316.1115-c

The endoplasmic reticulum (ER) is an intracellular membranous labyrinth that provides the entry point to the secretory pathway. During proteotoxic stress, the ER expands to cope with the added burden of misfolded or unfolded proteins. This is termed the unfolded protein response (UPR). Fumagilli et al. asked how, after the stress is removed, the cell returns its ER to normal levels. In cultured mammalian cells, they uncovered a process called “recovER-phagy.” During recovER-phagy, excess ER membranes are targeted for destruction. Unexpectedly, a component of the ER protein translocation machinery, Sec62, appears to provide a key autophagy receptor in this process, independently of its canonical function.

Nat. Cell Biol. 18, 1173 (2016).

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