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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

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Science  02 Dec 2016:
Vol. 354, Issue 6316, pp. 1160-1165
DOI: 10.1126/science.aaf2807

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vol. 354 no. 6316 1160-1165

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History: 
  • Received for publication January 18, 2016
  • Accepted for publication September 19, 2016

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Author Information

  1. Kristen E. Pauken1,
  2. Morgan A. Sammons2,
  3. Pamela M. Odorizzi1,
  4. Sasikanth Manne1,
  5. Jernej Godec3,4,
  6. Omar Khan1,
  7. Adam M. Drake2,
  8. Zeyu Chen1,
  9. Debattama R. Sen3,
  10. Makoto Kurachi1,
  11. R. Anthony Barnitz3,
  12. Caroline Bartman1,
  13. Bertram Bengsch1,
  14. Alexander C. Huang5,
  15. Jason M. Schenkel6,
  16. Golnaz Vahedi7,
  17. W. Nicholas Haining3,8,9,
  18. Shelley L. Berger2,
  19. E. John Wherry1,*
  1. 1Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  2. 2Departments of Cell and Developmental Biology, Genetics, and Biology, Penn Epigenetics Program, University of Pennsylvania, Philadelphia, PA, USA.
  3. 3Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  4. 4Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
  5. 5Department of Medicine and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  6. 6Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
  7. 7Department of Genetics and Institute for Immunology, University of Pennsylvania, Philadelphia, PA, USA.
  8. 8Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  9. 9Division of Hematology/Oncology, Children’s Hospital, Harvard Medical School, Boston, MA, USA.
  1. *Corresponding author. Email: wherry{at}mail.med.upenn.edu

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