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Science  16 Dec 2016:
Vol. 354, Issue 6318, pp. 1385
DOI: 10.1126/science.aal5242

An investigation by Imperial College into the Science Research Article “The protein LEM promotes CD8+ T cell immunity through effects on mitochondrial respiration” (1), which was the subject of an Editorial Expression of Concern in December 2015 (2), has now concluded that duplications and use of incorrect Western blots occurred during the preparation of several figures in the paper. The investigation also found that examples of the original Western blots and accompanying experimental details had been lost. The investigation found that the problematic figures had been prepared solely by corresponding author Ashton-Rickardt and he accepted full responsibility for them. In agreement with the recommendation of the investigation, Science is therefore retracting the Research Article.


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