Reports
Engineering extrinsic disorder to control protein activity in living cells
- Onur Dagliyan1,2,3,
- Miroslaw Tarnawski4,
- Pei-Hsuan Chu3,
- David Shirvanyants2,
- Ilme Schlichting4,
- Nikolay V. Dokholyan1,2,*,
- Klaus M. Hahn3,*
- 1Program in Molecular and Cellular Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- 2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- 3Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- 4Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany.
- ↵*Corresponding author. Email: khahn{at}med.unc.edu (K.M.H.); dokh{at}email.unc.edu (N.V.D.)
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Science 16 Dec 2016:
Vol. 354, Issue 6318, pp. 1441-1444
DOI: 10.1126/science.aah3404
Vol. 354, Issue 6318, pp. 1441-1444
DOI: 10.1126/science.aah3404
Onur Dagliyan
1Program in Molecular and Cellular Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
3Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Miroslaw Tarnawski
4Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany.
Pei-Hsuan Chu
3Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
David Shirvanyants
2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Ilme Schlichting
4Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany.
Nikolay V. Dokholyan
1Program in Molecular and Cellular Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Klaus M. Hahn
3Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
