Formation of α-chiral centers by asymmetric β-C(sp3)–H arylation, alkenylation, and alkynylation

See allHide authors and affiliations

Science  03 Feb 2017:
Vol. 355, Issue 6324, pp. 499-503
DOI: 10.1126/science.aal5175

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Expressed preferences among methyl groups

Targeting just one of the two equivalent branch ends in Y-shaped molecules is a particular challenge for catalysis. Enzymes manage to do it by grasping the whole molecule, octopus-like, but often enzymes cannot tolerate minor structural variations. Wu et al. produced an amide-directed palladium catalyst that, armed with oxazoline-derived chiral ligands, could reliably attack just one methyl member of isopropyl groups. The reaction successfully replaced C–H bonds with C–C bonds in a wide variety of aryl and vinyl coupling partners.

Science, this issue p. 499