Reports

Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division

See allHide authors and affiliations

Science  17 Feb 2017:
Vol. 355, Issue 6326, pp. 739-743
DOI: 10.1126/science.aak9973

Coordinating cell wall synthesis and cell division

Most bacteria are protected by peptidoglycan cell walls, which must be remodeled to split the cell. Cell division requires the tubulin homolog FtsZ, a highly conserved cytoskeletal polymer that specifies the future site of division. Bisson-Filho et al. and Yang et al. found that the dynamic treadmilling of FtsZ filaments controls both the location and activity of the associated cell wall synthetic enzymes. This creates discrete sites of cell wall synthesis that circle around the division plane to divide the cell.

Science, this issue p. 739, p. 744