Reports

GTPase activity–coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis

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Science  17 Feb 2017:
Vol. 355, Issue 6326, pp. 744-747
DOI: 10.1126/science.aak9995

Coordinating cell wall synthesis and cell division

Most bacteria are protected by peptidoglycan cell walls, which must be remodeled to split the cell. Cell division requires the tubulin homolog FtsZ, a highly conserved cytoskeletal polymer that specifies the future site of division. Bisson-Filho et al. and Yang et al. found that the dynamic treadmilling of FtsZ filaments controls both the location and activity of the associated cell wall synthetic enzymes. This creates discrete sites of cell wall synthesis that circle around the division plane to divide the cell.

Science, this issue p. 739, p. 744