Research Article

Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome

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Science  10 Mar 2017:
Vol. 355, Issue 6329, eaaf4791
DOI: 10.1126/science.aaf4791

Article Information

vol. 355 no. 6329

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History: 
  • Received for publication February 16, 2016
  • Accepted for publication February 1, 2017
  • .

Author Information

  1. Yue Shen1,2,10,11,*,
  2. Yun Wang1,11,*,
  3. Tai Chen1,11,*,
  4. Feng Gao1,
  5. Jianhui Gong1,
  6. Dariusz Abramczyk2,
  7. Roy Walker2,
  8. Hongcui Zhao1,
  9. Shihong Chen1,
  10. Wei Liu2,
  11. Yisha Luo2,
  12. Carolin A. Müller3,
  13. Adrien Paul-Dubois-Taine2,
  14. Bonnie Alver2,
  15. Giovanni Stracquadanio4,5,12,
  16. Leslie A. Mitchell6,
  17. Zhouqing Luo7,
  18. Yanqun Fan1,
  19. Baojin Zhou1,
  20. Bo Wen1,
  21. Fengji Tan1,
  22. Yujia Wang1,
  23. Jin Zi1,
  24. Zexiong Xie8,
  25. Bingzhi Li8,
  26. Kun Yang4,
  27. Sarah M. Richardson4,5,
  28. Hui Jiang1,
  29. Christopher E. French2,
  30. Conrad A. Nieduszynski3,
  31. Romain Koszul9,
  32. Adele L. Marston2,
  33. Yingjin Yuan8,
  34. Jian Wang1,
  35. Joel S. Bader5,6,
  36. Junbiao Dai7,
  37. Jef D. Boeke6,
  38. Xun Xu1,11,
  39. Yizhi Cai2,,
  40. Huanming Yang1,10,
  1. 1BGI-Shenzhen, Shenzhen 518083, China.
  2. 2School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.
  3. 3Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK.
  4. 4High-Throughput Biology Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
  5. 5Department of Biomedical Engineering, School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  6. 6Institute for Systems Genetics, New York University Langone Medical Center, ACLSW Room 503, 430 East 29th Street, New York, NY 10016, USA.
  7. 7Key Laboratory of Industrial Biocatalysis (Ministry of Education), Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  8. 8Key Laboratory of Systems Bioengineering (Ministry of Education), SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China.
  9. 9Department of Genomes and Genetics, Institut Pasteur/CNRS UMR3525, 25-28, Rue du Docteur Roux, 75724 Paris Cedex 15, France.
  10. 10James D. Watson Institute of Genome Sciences, Hangzhou 310058, China.
  11. 11BGI-Qingdao, Qingdao 266555, China.
  12. 12School of Computer Science and Electronic Engineering, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK.
  1. Corresponding authors: Email: yizhi.cai{at}ed.ac.uk (Y.C.); yanghm{at}genomics.cn (H.Y.)
  1. * These authors contributed equally to this work.

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