24 March 2017
Vol 355, Issue 6331

About The Cover

Cover image expansion

COVER Schematic representation of a DNA-protein hybrid object self-assembled from double-stranded DNA (gray) and a set of manufactured "staple" proteins (red). Each protein specifically recognizes and connects two sequences on the DNA template, thus folding it into a user-defined shape (for example, the tripod shown here). The hybrid objects self-assemble at near-physiological conditions from components that can be genetically encoded and produced in cells. As a result, this method has potential for intracellular customization of protein position or genomic DNA structure. See pages 1261 and 1283.
Illustration: C. Bickel/Science