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PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

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Science  24 Mar 2017:
Vol. 355, Issue 6331, pp. 1324-1330
DOI: 10.1126/science.aah6893

Article Information

vol. 355 no. 6331 1324-1330

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History: 
  • Received for publication August 2, 2016
  • Resubmitted December 23, 2016
  • Accepted for publication February 27, 2017
  • .

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Author Information

  1. Eneda Toska1,
  2. Hatice U. Osmanbeyoglu2,*,
  3. Pau Castel1,3,*,
  4. Carmen Chan1,
  5. Ronald C. Hendrickson4,
  6. Moshe Elkabets1,5,
  7. Maura N. Dickler6,
  8. Maurizio Scaltriti1,7,
  9. Christina S. Leslie2,
  10. Scott A. Armstrong8,9,,
  11. José Baselga1,6,
  1. 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.
  2. 2Computational Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 460, New York, NY 10065, USA.
  3. 3Helen Diller Family Comprehensive Cancer Center, University of California–San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA.
  4. 4Microchemistry and Proteomics Core Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  5. 5The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
  6. 6Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  7. 7Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  8. 8Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  9. 9Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
  1. Corresponding author. Email: scott_armstrong{at}dfci.harvard.edu (S.A.A.); baselgaj{at}mskcc.org (J.B.)
  1. * These authors contributed equally to this work.

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