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T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

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Science  31 Mar 2017:
Vol. 355, Issue 6332, pp. 1428-1433
DOI: 10.1126/science.aaf1292

Article Information

vol. 355 no. 6332 1428-1433

PubMed: 
Print ISSN: 
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History: 
  • Received for publication December 21, 2015
  • Resubmitted November 9, 2016
  • Accepted for publication February 17, 2017
  • .

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Author Information

  1. Enfu Hui1,*,
  2. Jeanne Cheung2,
  3. Jing Zhu2,
  4. Xiaolei Su1,
  5. Marcus J. Taylor1,
  6. Heidi A. Wallweber2,
  7. Dibyendu K. Sasmal3,
  8. Jun Huang3,
  9. Jeong M. Kim2,
  10. Ira Mellman2,,
  11. Ronald D. Vale1,
  1. 1Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
  2. 2Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.
  3. 3Institute for Molecular Engineering, University of Chicago, IL 60637, USA.
  1. Corresponding author. Email: mellman.ira{at}gene.com (I.M.); ron.vale{at}ucsf.edu (R.D.V.)
  • * Present address: Section of Cell and Developmental Biology, University of California, San Diego, CA 92093, USA.

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