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Research Article
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
- View ORCID ProfileAndrew S. Venteicher1,2,3,*,
- View ORCID ProfileItay Tirosh2,*,†,
- Christine Hebert1,2,
- Keren Yizhak1,2,
- View ORCID ProfileCyril Neftel1,2,4,
- Mariella G. Filbin1,2,5,
- Volker Hovestadt1,2,
- Leah E. Escalante1,2,
- McKenzie L. Shaw1,2,
- Christopher Rodman2,
- View ORCID ProfileShawn M. Gillespie1,
- Danielle Dionne2,
- View ORCID ProfileChristina C. Luo1,
- Hiranmayi Ravichandran1,
- View ORCID ProfileRavindra Mylvaganam1,
- Christopher Mount6,
- Maristela L. Onozato1,
- Brian V. Nahed3,
- Hiroaki Wakimoto3,
- William T. Curry3,
- A. John Iafrate1,
- Miguel N. Rivera1,2,
- Matthew P. Frosch1,
- View ORCID ProfileTodd R. Golub2,5,7,
- Priscilla K. Brastianos8,
- View ORCID ProfileGad Getz1,2,
- View ORCID ProfileAnoop P. Patel3,
- Michelle Monje6,
- View ORCID ProfileDaniel P. Cahill3,
- Orit Rozenblatt-Rosen2,
- View ORCID ProfileDavid N. Louis1,
- View ORCID ProfileBradley E. Bernstein1,2,
- View ORCID ProfileAviv Regev2,7,9,†,‡,
- View ORCID ProfileMario L. Suvà1,2,†,‡
- 1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
- 2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
- 3Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
- 4Institute of Pathology, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
- 5Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children’s Hospital Cancer Center, Boston, MA 02215, USA.
- 6Departments of Neurology, Neurosurgery, Pediatrics and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
- 7Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
- 8Departments of Medicine and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
- 9Koch Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- ↵†Corresponding author. Email: suva.mario{at}mgh.harvard.edu (M.L.S.); aregev{at}broadinstitute.org (A.R.); tirosh{at}broadinstitute.org (I.T.)
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Science 31 Mar 2017:
Vol. 355, Issue 6332, eaai8478
DOI: 10.1126/science.aai8478
Vol. 355, Issue 6332, eaai8478
DOI: 10.1126/science.aai8478
Andrew S. Venteicher
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
3Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Itay Tirosh
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Christine Hebert
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Keren Yizhak
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Cyril Neftel
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
4Institute of Pathology, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
Mariella G. Filbin
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
5Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children’s Hospital Cancer Center, Boston, MA 02215, USA.
Volker Hovestadt
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Leah E. Escalante
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
McKenzie L. Shaw
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Christopher Rodman
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Shawn M. Gillespie
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Danielle Dionne
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Christina C. Luo
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Hiranmayi Ravichandran
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Ravindra Mylvaganam
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Christopher Mount
6Departments of Neurology, Neurosurgery, Pediatrics and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Maristela L. Onozato
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Brian V. Nahed
3Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Hiroaki Wakimoto
3Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
William T. Curry
3Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
A. John Iafrate
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Miguel N. Rivera
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Matthew P. Frosch
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Todd R. Golub
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
5Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children’s Hospital Cancer Center, Boston, MA 02215, USA.
7Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Priscilla K. Brastianos
8Departments of Medicine and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Gad Getz
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Anoop P. Patel
3Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Michelle Monje
6Departments of Neurology, Neurosurgery, Pediatrics and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Daniel P. Cahill
3Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Orit Rozenblatt-Rosen
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
David N. Louis
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Bradley E. Bernstein
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Aviv Regev
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
7Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
9Koch Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Mario L. Suvà
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
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