Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

See allHide authors and affiliations

Science  28 Apr 2017:
Vol. 356, Issue 6336, eaal1641
DOI: 10.1126/science.aal1641

Single-cell diversity in the brain

The cells that make up an organism may all start from one genome, but somatic mutations mean that somewhere along the line of development, an organism's individual cellular genomes diverge. McConnell et al. review the implications and causes of single-cell genomic diversity for brain function. Somatic mutations caused by mobile genetic elements or errors in DNA repair may underlie certain neuropsychiatric disorders.

Science, this issue p. eaal1641

  • Full membership of the Brain Somatic Mosaicism Network is listed in the supplementary materials.