Research Article

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

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Science  05 May 2017:
Vol. 356, Issue 6337, pp. 513-519
DOI: 10.1126/science.aal3535

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  • RE: The epithelioid cell in Crohn's disease

    Epithelioid cell granulomas are present in about half of the patients with Crohn's disease. Epithelioid cells, however, have not been demonstrated in the experimentally induced colitis described by Ip et al (1). In other granulomatous inflammatory disorders such as tuberculosis and sarcoidosis, the epithelioid cells are 'primarily biosynthetic rather than phagocytic' (2). Epithelioid cells have been produced in an autoimmune model of tuberculoid leprosy using an antigen in human sensory peripheral nerve . The ultrastructural appearance of these cells are similar to those in tuberculosis and sarcoidosis (3). In patients with tuberculoid leprosy, the epithelioid cells stain positively with CD123 (4), indicating that they are plasmacytoid dendritic cells (pDCs). In the lymph nodes of patients with tuberculosis and sarcoidosis, the cells stain positively with CD123 (5). pDCs express toll like receptor (TLR) 9, and chloroquine is an inhibitor of this receptor (6). If the granulomatous cells in patients with Crohn's disease stain positively with CD123, then chloroquine could be used as a treatment for this disease.
    1.WKE. Ip et al. Science 356, 513 (2017). 2. W. Jones Williams et al. Postgrad Med 46, 496 (1970). 3. C.L Crawford et al, Nature 265, 223 (1977). 4. P.R. Andrade et al, Br J Dermatol. 172, 268 (2015). 5. M.Cella et al. Nature Med 8, 919 (1999). 6. A. Scharfe-Nugent et al. J Immunol 188, 5706 (2012).

    Competing Interests: None declared.