Research Article

Impact of cytosine methylation on DNA binding specificities of human transcription factors

See allHide authors and affiliations

Science  05 May 2017:
Vol. 356, Issue 6337, eaaj2239
DOI: 10.1126/science.aaj2239

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Positives and negatives of methylated CpG

When the DNA bases cytosine and guanine are next to each other, a methyl group is generally added to the pyrimidine, generating a mCpG dinucleotide. This modification alters DNA structure but can also affect function by inhibiting transcription factor (TF) binding. Yin et al. systematically analyzed the effect of CpG methylation on the binding of 542 human TFs (see the Perspective by Hughes and Lambert). In addition to inhibiting binding of some TFs, they found that mCpGs can promote binding of others, particularly TFs involved in development, such as homeodomain proteins.

Science, this issue p. eaaj2239; see also p. 489

View Full Text