Tudor-SN–mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition

See allHide authors and affiliations

Science  26 May 2017:
Vol. 356, Issue 6340, pp. 859-862
DOI: 10.1126/science.aai9372

Breaking down miRNAs

Although much work has examined microRNA (miRNA) biogenesis, relatively little is known about miRNA decay. Elbarbary et al. now identify Tudor-SN, an endonuclease that interacts with the RNA-induced silencing complex. Tudor-SN targets miRNAs at CA and UA dinucleotides located more than five nucleotides from miRNA ends. Tudor-SN-mediated miRNA decay removes miRNAs that silence genes encoding proteins that are critical for the G1-to-S phase transition in the cell cycle.

Science, this issue p. 859