02 June 2017
Vol 356, Issue 6341

About The Cover

Cover image expansion

COVER The Lassa virus glycoprotein in its trimeric, viral surface state (orange) bound to a fragment of a neutralizing antibody from a human survivor (white). A second, empty antibody binding site is illuminated. Bound antibody bridges different monomers in the trimer to prevent conformational changes required for infection. The crystal structure determined by Hastie et al. provides a template for vaccine development. See page 923.
Illustration: C. Bickel/Science; Coordinates: Kathryn Hastie and Erica Ollmann Saphire, The Scripps Research Institute