Contents
16 June 2017
Vol 356, Issue 6343
Vol 356, Issue 6343
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Designers squabble over giant Chinese scope
Influential optics team clashes with astronomers over plans for 12-meter telescope.
- NIH abandons grant cap, offers new help to younger scientists
After controversy, agency aims to build $1 billion “next-generation” fund.
- Mini-livers reveal fine details of organ development
3D structure arises in a dish as cell types interact to promote differentiation.
- Spooky action achieved at record distance
Entangled photons from Chinese satellite foreshadow space-based quantum network.
- In a major shift, cancer drugs go ‘tissue-agnostic’
Encouraged by an FDA approval, companies design cancer drugs to work in any solid tumor.
- Supply of promising T cell therapy is strained
Surging demand for modified immune cells causes some cancer trials to run short.
Feature
- Chimps in waiting
Two years after biomedical research on chimpanzees ended, why have so few beenretired to sanctuaries?
Working Life
Letters
Books et al.
- There's more to a meal
A psychologist probes the invisible influences that shape the dining experience
- Unlikely allies
An environmental toxicologist advocates embracing microbes as partners in human and agricultural health
Policy Forum
- Linking job loss, inequality, mental health, and education
Job destruction knocks many youth off the path to college
Perspectives
- A composite window into human history
Better integration of ancient DNA studies with archaeology promises deeper insights
- Growing anisotropic crystals at the nanoscale
Single-nanoparticle imaging and theoretical modeling can guide synthesis strategies
- Glycophorin alleles link to malaria protection
Genome-wide association studies identify variants in the human glycophorin ABE locus
- Deciphering microglial diversity in Alzheimer's disease
A subset of microglia appear primed to protect against AD neurodegeneration
- Scaling pain threshold with microRNAs
Tuning pain with a defined microRNA cluster
- Tracking the dynamics of electron expulsion
Electron holography is used to map out the wave function of a photo-emitted electron
Review
Research Articles
- Tubular clathrin/AP-2 lattices pinch collagen fibers to support 3D cell migration
“Frustrated” coated pits associate with collagen fibers and appear to promote cell adhesion in three-dimensional collagen networks.
- Resistance to malaria through structural variation of red blood cell invasion receptors
Structural variants are mapped that are correlated with a reduced risk of severe malaria.
- Satellite-based entanglement distribution over 1200 kilometers
Entangled photons are distributed over vast distances using a satellite-to-ground link.
- Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions
Continuous-flow technology is devised and implemented for manufacture of a drug candidate in clinical trials.
Reports
- Coherent imaging of an attosecond electron wave packet
Attosecond pulses image the quantum mechanical nodal structure as an electron is expelled from a neon atom.
- Rapid cooling and cold storage in a silicic magma reservoir recorded in individual crystals
Taupo Volcanic Zone magma spent more than 90% of its life deep and crystalline before rapid shallow accumulation and eruption.
- Recurring and triggered slow-slip events near the trench at the Nankai Trough subduction megathrust
Eight slow-slip events over 6 years accommodated up to 50% of the fault slip on the Nankai megathrust.
- Seasonal water storage, stress modulation, and California seismicity
Microseismicity is modulated by the seasonal hydrological cycle in California.
- Dual-comb spectroscopy of water vapor with a free-running semiconductor disk laser
The slight differences between two optical frequency combs from the same laser source capture precise microwave intervals.
- miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes
A cluster of microRNAs regulates both normal pain sensitivity and the pathological responses of chronic pain.
- Plants transfer lipids to sustain colonization by mutualistic mycorrhizal and parasitic fungi
Lipid transfer provides symbiotic fungi associated with plant roots with a source of carbon.
- Fatty acids in arbuscular mycorrhizal fungi are synthesized by the host plant
Lipid transfer provides symbiotic fungi associated with plant roots with a source of carbon.
- Increase in predator-prey size ratios throughout the Phanerozoic history of marine ecosystems
The size of marine invertebrate predators has increased over the past 500 million years.
- Satellites reveal contrasting responses of regional climate to the widespread greening of Earth
Increasing terrestrial biomass has important impacts on the climate that affects it.
- Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2
An early window of stress susceptibility defines a mouse’s response to stress in adulthood.
- Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth
A transcriptional regulatory mechanism enables cellular adaptation to nutrient availability and supports cancer metabolism.
- Controlling guest conformation for efficient purification of butadiene
The weaker adsorption of 1,3-butadiene in a metal-organic framework enables its separation from other C4 hydrocarbons.
Technical Comments
About The Cover
COVER Artist's rendering of the quantum science satellite Micius, distributing two entangled photons to two locations separated by ~1200 kilometers on Earth. This approach is much more efficient than direct transmission through optical fibers, thus opening up a new avenue for global-scale quantum networks and foundational quantum optics experiments in space. See pages 1110 and 1140.
Illustration: C. Bickel/Science; Satellite model credit: Jian-Wei Pan
