Research Article

Reconfiguration of DNA molecular arrays driven by information relay

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Science  28 Jul 2017:
Vol. 357, Issue 6349, eaan3377
DOI: 10.1126/science.aan3377

Relaying information on DNA tiles

Arrays of modular DNA units can relay information by transforming their internal shape in response to binding of DNA trigger strands. Song et al. synthesized rectangular arrays of double-stranded DNA (see the Perspective by Yang and Lin). Transient square configurations transform into two stable rectangular structures by pinching across a pair of opposing vertices. Binding of DNA trigger strands causes switching into the alternative stable configuration. The tiles thus create a cascade of transformations along a particular pathway, thereby transmitting information about where binding occurred.

Science, this issue p. eaan3377; see also p. 352

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