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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

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Science  04 Aug 2017:
Vol. 357, Issue 6350, pp. 507-511
DOI: 10.1126/science.aah5582

Article Information

vol. 357 no. 6350 507-511

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History: 
  • Received for publication July 13, 2016
  • Resubmitted May 4, 2017
  • Accepted for publication June 21, 2017
  • .

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Author Information

  1. Robert W. Myers1,*,,
  2. Hong-Ping Guan2,*,
  3. Juliann Ehrhart3,
  4. Aleksandr Petrov2,
  5. Srinivasa Prahalada3,
  6. Effie Tozzo2,
  7. Xiaodong Yang2,
  8. Marc M. Kurtz1,
  9. Maria Trujillo4,
  10. Dinko Gonzalez Trotter5,
  11. Danqing Feng6,
  12. Shiyao Xu7,
  13. George Eiermann4,
  14. Marie A. Holahan5,
  15. Daniel Rubins5,
  16. Stacey Conarello4,
  17. Xiaoda Niu1,
  18. Sandra C. Souza2,,
  19. Corin Miller5,
  20. Jinqi Liu2,
  21. Ku Lu2,
  22. Wen Feng1,
  23. Ying Li2,
  24. Ronald E. Painter1,
  25. James A. Milligan1,
  26. Huaibing He7,
  27. Franklin Liu2,
  28. Aimie Ogawa1,
  29. Douglas Wisniewski1,
  30. Rory J. Rohm2,
  31. Liyang Wang1,
  32. Michelle Bunzel5,
  33. Ying Qian2,
  34. Wei Zhu2,
  35. Hongwu Wang6,
  36. Bindu Bennet3,
  37. Lisa LaFranco Scheuch3,
  38. Guillermo E. Fernandez3,
  39. Cai Li4,
  40. Michael Klimas5,
  41. Gaochao Zhou1,
  42. Margaret van Heek4,
  43. Tesfaye Biftu6,
  44. Ann Weber6,
  45. David E. Kelley2,
  46. Nancy Thornberry2,
  47. Mark D. Erion2,
  48. Daniel M. Kemp2,
  49. Iyassu K. Sebhat6,
  1. 1In Vitro Pharmacology, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  2. 2Biology-Discovery, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  3. 3Safety Assessment and Laboratory Animal Resources, Merck Research Laboratories, West Point, PA 19486, USA.
  4. 4In Vivo Pharmacology, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  5. 5Translational Imaging and Biomarkers Departments, Merck Research Laboratories, West Point, PA 19486, USA.
  6. 6Medicinal Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  7. 7PPDM Preclinical ADME Departments, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  1. Corresponding author. Email: robertwmyersphd{at}gmail.com (R.W.M.); iyassu{at}kallyope.com (I.K.S.)
  1. * These authors contributed equally to this work.

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