PerspectiveCell Biology

Actin divides to conquer

See allHide authors and affiliations

Science  25 Aug 2017:
Vol. 357, Issue 6353, pp. 756-757
DOI: 10.1126/science.aao2461

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Aneuploidy is a cellular condition characterized by the gain or loss of specific chromosomes. This can arise from chromosome segregation problems during cell division in the germ line (a process called meiosis), and is the main cause of age-related female infertility, spontaneous miscarriage, and developmental disorders in humans. To segregate chromosomes, cells rely on a spindle-shaped structure made up of filaments called microtubules. On page 772 of this issue, Mogessie and Schuh (1) show that another cytoskeleton filament—actin—can be found in close association with microtubules in the spindle and promotes chromosome segregation fidelity during meiosis in mammalian oocytes.